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Fructose 2,6‐bisphosphate and the control of glycolysis in bovine spermatozoa
Author(s) -
Philippe Benoît,
Rousseau Guy G.,
Hue Louis
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80532-4
Subject(s) - glycolysis , fructose 2,6 bisphosphate , fructose , chemistry , biochemistry , metabolism , phosphofructokinase
Epididymal bovine sperm contain fructose‐1,6‐bisphosphatase activity which is inhibited by AMP and by fructose 2,6‐bisphosphate. Sperm phosphofructokinase displays kinetic characteristics that are typical of the F‐type and it is stimulated by fructose 2,6‐bisphosphate. The concentration of sperm fructose 2,6‐bisphosphate remained unaffected at 1–2 μM when the glycolytic rate was either increased by glucose, caffeine or antimycin, or decreased by α‐chlorohydrin or 6‐chloro‐6‐deoxyglucose.