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Protein that induces cell differentiation causes nicks in double‐stranded DNA
Author(s) -
Weisinger Gary,
Korn Alex P.,
Sachs Leo
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80520-8
Subject(s) - microbiology and biotechnology , dna , chemistry , double stranded , biophysics , biochemistry , biology
The growth and differentiation of myeloid hematopoietic cells are regulated by different macrophage and granulocyte inducing proteins, those that induce growth and others that induce differentiation. The proteins that induce differentiation but not those that induce growth bind to double‐stranded DNA. We now report that purified myeloid cell differentiation‐inducing protein causes single strand breaks (nicks) in double‐stranded DNA. This DNA nicking may initiate the changes in gene expression that are required for differentiation.