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Lipoprotein‐binding proteins in the human platelet plasma membrane
Author(s) -
Koller Elisabeth
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80518-x
Subject(s) - suramin , lysine , chemistry , platelet , biochemistry , lipoprotein , membrane , heparin , arginine , membrane protein , blot , plasma protein binding , blood proteins , receptor , amino acid , cholesterol , biology , gene , immunology
The binding of homologous plasma lipoproteins to specific receptor proteins in the plasma membrane of human blood platelets was studied by ligand blotting techniques. HDL 3 , HDL 2 and LDL showed saturable binding to three bands of 156, 130 and 115 kDa, respectively. This binding was not markedly affected by the presence or absence of Ca 2+ nor by covalent modification of lysine and arginine residues of the apoprotein moieties. However, it can be almost completely reversed by the addition of heparin or suramin.