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Enhancement in anti‐Semliki Forest virus activity of ds RNA by a muramyl dipeptide
Author(s) -
George C.X.,
Jain R.K.,
Gupta C.M.,
Anand Nitya
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80506-3
Subject(s) - semliki forest virus , muramyl dipeptide , rna , chemistry , dipeptide , virus , virology , biology , biochemistry , amino acid , in vitro , gene
Antiviral activity of an interferon‐inducing mycoviral ds RNA against Semliki Forest virus infection was considerably enhanced by N ‐palmitoylmuramyl‐L‐alanyl‐D‐isoglutamine (PMDP), a new muramyl dipeptide. This enhancement in activity was not due to increased production of interferon, but resulted probably from a PMDP‐induced increase in nonspecific resistance to infection. These results indicate that a combined treatment with an interferon inducer and muramyl dipeptide may prove highly useful to control effectively viral infections.