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Low level of lipid peroxidation in newborn rats
Author(s) -
Devasagayam Thomas P.A.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80480-x
Subject(s) - lipid peroxidation , chemistry , biochemistry , oxidative stress
Hepatic rough and smooth microsomes of newborn rats show less sensitivity to ascorbate‐ and NADPH‐induced lipid peroxidation as compared to those of adult rats. Though optimum concentrations of Fe 2+ , ascorbate and Fe 3+ significantly increase lipid peroxidation in both age groups, the lipid peroxidation observed in newborns is much less compared with that of adults. Microsomal fractions from newborn rats contain significantly lower amounts of phospholipid, NADPH cytochrome c reductase, cytochrome P‐450 and a lower degree of unsaturation in lipids. These fractions also exhibit high cholesterol:phospholipid ratios. The resistance to lipid peroxidation observed in the newborns appears to be due to the low availability of substrate and high cholesterol:phospholipid ratio.