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Kinetic alterations of cytochrome‐ c oxidase in cystic fibrosis
Author(s) -
Battino Maurizio,
Rugolo Michela,
Romeo Giovanni,
Lenaz Giorgio
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80470-7
Subject(s) - cytochrome c oxidase , cystic fibrosis , cytochrome , chemistry , oxidoreductase , cytochrome c , enzyme , kinetics , electron transport complex iv , oxidase test , microbiology and biotechnology , biochemistry , biology , medicine , mitochondrion , physics , quantum mechanics
We compared the kinetics of cytochrome‐ c oxidase (cytochrome‐ c : oxygen oxidoreductase, EC 1.9.3.1) in fibroblasts derived from normal and cystic fibrosis individuals. The K m of the enzyme for reduced cytochrome c was significantly increased in CF cells; the change, however, was observed only at temperatures above 25°C. The V max values were comparable in both types of individuals.