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Nerve growth factor induces mast cell degranulation without changing intracellular calcium levels
Author(s) -
Mazurek N.,
Weskamp G.,
Erne P.,
Otten U.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80428-8
Subject(s) - degranulation , nerve growth factor , extracellular , calcium , intracellular , mast cell , calcium in biology , protein kinase c , chemistry , microbiology and biotechnology , medicine , endocrinology , biology , kinase , immunology , biochemistry , receptor
Nerve growth factor (NGF) induces degranulation of rat peritoneal mast cells (RPMC) in a dose‐dependent manner, providing direct evidence for its action on non‐neuronal tissues. Activation of RPMC by NGF depends on lysophosphatidylserine and extracellular calcium. NGF‐mediated RPMC degranulation is not coupled to a transient increase in intracellular free calcium ([Ca 2+ ]). It is suggested that NGF has a unique mode of action independent of ([Ca 2+ ]) i and presumably also without involving protein kinase C activation as indicated by the effects of phorbol esters and NGF on antigen‐evoked [Ca 2+ ] i rise.