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gp 140, the C3d/EBV receptor (CR2), is phosphorylated upon in vitro activation of human peripheral B lymphocytes
Author(s) -
Barel Monique,
Vazquez Aimé,
Charriaut Christiane,
Aufredou Maria Thérèse,
Galanauc Pierre,
Frade Raymond
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80356-8
Subject(s) - phosphorylation , in vitro , receptor , chemistry , peripheral , lymphocyte , microbiology and biotechnology , lymphocyte activation , cancer research , biology , immunology , t cell , biochemistry , medicine , immune system
gp 140, the C3d/EBV receptor (CR2), is a specific marker of human B lymphocytes. Very recent data suggest that CR2 is a membrane site involved in early B cell activation. These properties of CR2 led us to analyze the molecular events associated with gp 140. We analyzed whether in some conditions of B lymphocyte activation, CR2 could be phosphorylated. We have found that when highly enriched peripheral B cells were cultured for 48 h with anti‐μ Ab and/or SAC, in order to provide an optimal activating signal, phosphorylation of the CR2 was induced.