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Maitotoxin stimulat es the formation of inositol phosphates in rat aortic myocytes
Author(s) -
Berta Philippe,
Sladeczek Fritz,
Derancourt Jean,
Durand Monique,
Travo Pierre,
Haiech Jacques
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80355-6
Subject(s) - chemistry , inositol , marine toxin , calcium , nifedipine , calcium channel , voltage dependent calcium channel , diltiazem , inositol phosphate , pharmacology , biochemistry , biology , receptor , toxin , organic chemistry
Maitotoxin is the most potent of the known marine toxins. The effect of maitotoxin on muscle contraction or hormone release was consistent with its action on the voltage‐sensitive channel. Indeed, calcium antagonists such as nifedipine or diltiazem were able to reverse the maitotoxin effects. Using smooth muscle cells, we have analysed the effects of maitotoxin on the inositol phosphate metabolism. Maitotoxin stimulates the inositol phosphate formation (5 ± 1.8‐fold in the presence of 10 mM LiCI). Moreover, this effect is not reversed, even partially by calcium antagonists, by α 1 antagonists and is not mimicked by Ca 2+ ionophores such as A23187 or calcium agonists such as Bay‐K 8644. The action of maitotoxin is further discussed in this paper.