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Increased basal gluconeogenesis in the aged rat
Author(s) -
Satrústegui Jorgina,
Cuezva José M.,
Machado Alberto
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80318-0
Subject(s) - gluconeogenesis , medicine , basal (medicine) , endocrinology , glucagon , chemistry , plasma glucose , insulin , in vivo , biology , metabolism , microbiology and biotechnology
Post‐absorptive gluconeogenesis from lactate measured in vivo increases 3‐fold in 24‐month‐old rats compared to 3‐month‐old animals. Fractional lactate turnover rates showed no significant differences between the two groups of animals. Lower plasma glucose concentrations and insulin‐glucagon ratios may explain the increase in gluconeogenesis observed in aged rats.