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Selective phosphorylation of human DNA methyltransferase by protein kinase C
Author(s) -
DePaoli-Roach Anna,
Roach Peter J.,
Zucker Keith E.,
Smith Steven S.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80316-7
Subject(s) - protein kinase a , protein kinase c , biochemistry , dna methylation , methyltransferase , phosphorylation , methylation , dna , biology , protein phosphorylation , map2k7 , chemistry , cyclin dependent kinase 2 , microbiology and biotechnology , gene , gene expression
Human DNA methyltransferase, the enzyme thought to be responsible for the somatic inheritance of patterns of DNA methylation, is an effective substrate for phosphorylation by protein kinase C. This provides a plausible mechanistic link between the action of tumor promoting phorbol esters, which stimulate protein kinase C, and abnormal patterns of DNA methylation often observed in transformed cells.