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Synthesis of seven different homologous phytochelatins in metal‐exposed Schizosaccharomyces pombe cells
Author(s) -
Grill E.,
Winnacker E.-L.,
Zenk M.H.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80309-x
Subject(s) - schizosaccharomyces pombe , yeast , schizosaccharomyces , phytochelatin , glutathione , metal , chemistry , peptide , fission , homologous chromosome , biochemistry , stereochemistry , biology , saccharomyces cerevisiae , gene , organic chemistry , enzyme , physics , quantum mechanics , neutron
The family of heavy metal‐sequestering peptides with the formula (γ‐Glu‐Cys) n Gly; n = 2–8), the phytochelatins (PCs), are not restricted to higher plants. In Schizosaccharomyces pombe the occurrence of two of these peptides has previously been reported. Reinvestigation of the peptide pattern of the heavy metal‐exposed fission yeast led to the discovery of five additional peptides, a pattern which now corresponds qualitatively exactly to the one in higher plants. From the kinetics of induction we propose that PCs are synthesized by consumption of glutathione or its biosynthetic precursor.