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Type VI collagen is a major component of the human cornea
Author(s) -
Zimmermann Dieter R.,
Trüeb Beat,
Winterhalter Kaspar H.,
Witmer Rudolf,
Fischer René W.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80297-6
Subject(s) - cornea , extracellular matrix , stroma , collagen, type i, alpha 1 , type i collagen , chemistry , type iv collagen , immunofluorescence , microbiology and biotechnology , biochemistry , biology , antibody , immunohistochemistry , immunology , laminin , endocrinology , neuroscience
Collagen type VI is shown to be present in the human cornea. This finding is based on comparative peptide mapping relative to type VI collagen isolated from placenta and on immunoblotting using antibodies specific for human type VI collagen. Scanning of polyacrylamide gels indicates that type VI collagen comprises as much as one quarter of the dry weight of the cornea. Indirect immunofluorescence shows this collagen to be distributed throughout the corneal stroma. Thus, type VI collagen must be considered a major component of the extracellular matrix of the human cornea.