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C‐ras H and ornithine decarboxylase are induced by oestradiol‐17β in the mouse uterine luminal epithelium independently of the proliferative status of the cell
Author(s) -
Cheng Shirley V.Y.,
Pollard Jeffrey W.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80269-1
Subject(s) - ornithine decarboxylase , dna synthesis , ovariectomized rat , medicine , epithelium , endocrinology , cell growth , microbiology and biotechnology , messenger rna , chemistry , biology , enzyme , estrogen , dna , biochemistry , gene , genetics
Oestradiol‐17 β (E 2 ) treatment of the ovariectomized mouse results in a synchronised wave of cell proliferation in the uterine luminal epithelium. At the peak of DNA synthesis the mRNA level of the c‐ras H protooncogene and ornithine decarboxylase were significantly increased. Progesterone treatment completely inhibits the E 2 induced wave of DNA synthesis but does not greatly influence the level of these 2 mRNAs. Thus in the uterine luminal epithelium E 2 regulates the level of ornithine decarboxylase and c‐ras H independently of cell proliferation.