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Comparison of the internalization efficiency of LDL and transferrin receptors on L 2 C guinea pig lymphocytes
Author(s) -
Vidal M.,
Sainte-Marie J.,
Philippot J.R.,
Bienvenue A.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80255-1
Subject(s) - internalization , receptor , transferrin receptor , transferrin , guinea pig , chemistry , kinetics , ldl receptor , dissociation (chemistry) , microbiology and biotechnology , dissociation constant , biochemistry , biophysics , biology , endocrinology , lipoprotein , cholesterol , physics , quantum mechanics
We demonstrate that L 2 C lymphocytes have about 10‐times more receptors for transferrin (TO than healthy lymphocytes, as has been shown in the case of LDL receptors. The dissociation constant is the same in the two cell types (about 4 × 10 −7 M). In contrast to LDL, Tf enters L 2 C lymphocytes with very rapid kinetics. It is shown by cross‐reaction that each receptor is internalized independently of the other.