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Spatial structures in mitochondrial suspension induced by cation efflux
Author(s) -
Holmuhamedov E.L.,
Evtodienko Yu.V.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80189-2
Subject(s) - ruthenium red , egta , divalent , efflux , mitochondrion , biophysics , suspension (topology) , chemistry , respiratory chain , inner mitochondrial membrane , ion transporter , biochemistry , membrane , calcium , biology , organic chemistry , mathematics , homotopy , pure mathematics
The formation of spatial structures in a thin unstirred layer of a mitochondrial suspension has been studied. It is shown that the structure formation depends on the state of the ion‐transporting systems of mitochondria and that pattern development coincides with the activation of cation efflux from preloaded mitochondria. Spatial structure formation is an energy‐dependent process and is suppressed by respiratory chain inhibitors. Patterning is also inhibited by EGTA, EDTA and ruthenium red, reflecting the requirement for divalent cation translocation in mitochondria for the studied phenomenon.