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Complete tyrosine O ‐sulfation of gastrin in adult and neonatal cat pancreas
Author(s) -
Cantor P.,
Andersen B.N.,
Rehfeld J.F.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80175-2
Subject(s) - gastrin , sulfation , medicine , endocrinology , pancreas , tyrosine , antrum , chemistry , duodenum , stomach , biochemistry , secretion
We have found gastrin in both the adult and neonatal cat pancreas. In contrast with the main production sites, antrum and duodenum, gastrin in the pancreas occurs in a single molecular form, tyrosine O ‐sulfated gastrin‐17. Since tyrosine sulfation increases the pancreozymic effect of gastrin, the complete sulfation seems functionally expedient.