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Primary structure of the α‐subunit of bovine adenylate cyclase‐stimulating G‐protein deduced from the cDNA sequence
Author(s) -
Nukada Toshihide,
Tanabe Tsutomu,
Takahashi Hideo,
Noda Masaharu,
Hirose Tadaaki,
Inayama Seiichi,
Numa Shosaku
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80164-8
Subject(s) - adenylate kinase , protein primary structure , complementary dna , protein subunit , cyclase , chemistry , microbiology and biotechnology , sequence (biology) , peptide sequence , biology , biochemistry , gene , enzyme
The primary structure of the α‐subunit of the adenylate cyclase‐stimulating G‐protein (G s ) has been deduced from the nucleotide sequence of cloned DNA complementary to the bovine cerebral mRNA encoding the polypeptide. Comparison of the amino acid sequences of the α‐subunits of G s and transducin reveals that some of the highly conserved regions show sequence homology with elongation factor‐Tu and ras p21 proteins and correspond to functional regions of guanine nucleotide‐binding proteins.