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Intracellular Ca 2+ ‐calmodulin system involved in the palytoxin‐induced K + release from rabbit erythrocytes
Author(s) -
Nagase Hiromi,
Ozaki Hiroshi,
Karaki Hideaki,
Urakawa Norimoto
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80145-4
Subject(s) - palytoxin , intracellular , calmodulin , extracellular , chemistry , egta , antagonist , biophysics , chelation , biochemistry , calcium , stereochemistry , biology , receptor , enzyme , inorganic chemistry , toxin , organic chemistry
Palytoxin (PTX) caused K + release from rabbit erythrocytes which was dependent on the concentrations of extracellular Ca 2+ and PTX. In a Ca 2+ ‐free solution, PTX still caused a slow K + release. An intracellular Ca 2+ antagonist, TMB‐8, an intracellular Ca 2+ chelator, quin 2, and calmodulin inhibitors, prenylamine, W‐7 and W‐5, inhibited the PTX‐induced K + release in a Ca 2+ ‐free solution. These results suggest that the PTX‐induced K + release is dependent on the process including intracellular Ca 2+ and calmodulin.