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Mobilization of intracellular calcium by glucagon and cyclic AMP analogues in isolated rat hepatocytes
Author(s) -
Mauger Jean-Pierre,
Claret Michel
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80140-5
Subject(s) - glucagon , mobilization , intracellular , calcium , chemistry , calcium in biology , microbiology and biotechnology , biochemistry , endocrinology , medicine , biophysics , biology , hormone , archaeology , organic chemistry , history
Separate or combined addition of cyclic AMP‐dependent and Ca 2+ ‐linked hormones to isolated rat hepatocytes suspended in a low Ca 2+ medium reduced the total cellular Ca. When the hormones were administered together, their effects were not additive. This suggests that both types of hormones mobilize Ca 2+ from a common intracellular pool. In the presence of 1.8 mM extracellular Ca 2+ , the Ca 2+ influx counterbalanced or even exceeded the hormone‐induced Ca 2+ loss, depending on the ability of the hormones to stimulate the Ca 2+ influx.