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Bleomycin‐detectable iron in plasma from Plasmodium vinckei vinckei ‐infecied mice
Author(s) -
Buffinton G.D.,
Cowden W.B.,
Hunt N.H.,
Clark I.A.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80131-4
Subject(s) - bleomycin , in vivo , chemistry , biochemistry , biology , microbiology and biotechnology , genetics , chemotherapy
(1) Plasma from mice heavily parasitized by Plasmodium vinckei vinckei was found to contain micromolar levels of iron as detected by the ‘bleomycin assay’ (slightly modified) of Gutteridge et al. [(1981) Biochem. J. 199, 263‐265]. Uninfected mouse plasma contained little or no bleomycin‐detectable iron. (2) Plasma ultrafiltrate from infected mice contained no bleomycin‐detectable iron, indicating that such iron was associated with the protein/macromolecule fraction. (3) We speculate that this iron could catalyse reduction of peroxides in vivo and thus play a role in malaria pathology.