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Indole ring binds to 7‐methylguanine base by π‐π stacking interaction
Author(s) -
Kamiichi Katsuhisa,
Danshita Masaya,
Minamino Naoko,
Doi Mitsunobu,
Ishida Toshimasa,
Inoue Masatoshi
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80129-6
Subject(s) - stacking , indole test , tryptamine , ring (chemistry) , chemistry , base (topology) , ribose , stereochemistry , crystallography , biochemistry , organic chemistry , enzyme , mathematics , mathematical analysis
Strong π‐π stacking interaction between the indole ring and 7‐methylguanine base was shown by X‐ray crystal analysis of the 7‐methylguanosine 5'‐monophosphate‐tryptamine complex. This interaction appears to be strengthened by the attachment of ribose and phosphate groups to the base.