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Cell nuclei generate DNA‐nicking Superoxide radicals
Author(s) -
Peskin Alexander V.,
Shlyahova Larisa
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80109-0
Subject(s) - radical , superoxide dismutase , catalase , superoxide , dna , chemistry , oxygen , reactive oxygen species , dna damage , biochemistry , microbiology and biotechnology , biophysics , enzyme , biology , organic chemistry
Rat liver nuclei generate Superoxide radicals in the presence of NADPH. Active oxygen species induced nicks in nuclear DNA. This was prevented by Superoxide dismutase and catalase as well as by anaerobiosis. EDTA‐Fe 3+ dramatically increased the active oxygen‐dependent DNA nicking.