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T7 and E.coli share homology for replication‐related gene products
Author(s) -
Toh Hiroyuki
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80093-x
Subject(s) - gene , genetics , primase , biology , dna replication , homology (biology) , genome , bacteriophage , dna , exonuclease , escherichia coli , microbiology and biotechnology , dna polymerase , polymerase chain reaction , reverse transcriptase
Recently, the complete nucleotide sequence of the bacteriophage T7 genome was determined and 50 genes were identified on the genome. We compared amino acid sequences of all the gene products of T7 and replication‐related gene products of E.coli . As a result, we found that T7 and E.coli share homology for each pair of exonuclease, DNA primase and helix‐destabilizing protein. For E.coli , these gene products are known to be involved in the process of discontinuous DNA replication. These observations suggest that T7 and E.coli have a common origin for a part of their replication systems.