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Identification of proliferation‐sensitive human proteins amongst components of the 40 S hnRNP particles
Author(s) -
Celis Julio E.,
Bravo Rodrigo,
Arenstorf Hartwig P.,
LeStourgeon Wallace M.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80059-x
Subject(s) - hela , function (biology) , core protein , human proteins , microbiology and biotechnology , chemistry , biology , biochemistry , computational biology , cell , gene
The core proteins of HeLa 40 S hnRNP monoparticles have been identified in the HeLa protein catalogue. Human proteins previously indemnified as proliferation‐sensitive [NEPHGE 21 and 17; Bravo, R. and Celis, J.E. (1982) Clin. Chem. 28, 766], as well as two proteins characterized in this study (NEPHGE 16 W and 16 Wl), are shown to be components of these particles. These basic nuclear polypeptides correspond to core proteins a l , B la , B 2 and C 4 , respectively. The significance of these results in terms of composition and function of hnRNP particles is discussed.