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Glucosamine is a normal component of liver glycogen
Author(s) -
Kirkman Brent R.,
Whelan William J.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80041-2
Subject(s) - glucosamine , galactosamine , glycogen , chemistry , biochemistry , endogeny , glycogen synthase , glycogen branching enzyme
There have been several reports of the incorporation of glucosamine into liver glycogen by an intraperitoneal injection of galactosamine, but it has not previously been considered that glucosamine is a normal component of liver glycogen. We now report that glucosamine occurs endogenously in rabbit‐ and pig‐liver glycogens in the amount of about 1 nmol per 10 mg glycogen. Like the glucosamine incorporated by exogenous administration of galactosamine, the endogenous glucosamine takes the place of 1,4‐linked α‐glucose residues. It is found in both the outer and inner chains of the glycogen molecule.