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Age‐dependent changes in the level of a 34 kDa DNA‐binding protein in developing chick embryo liver
Author(s) -
David E.,
Shanmugam G.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)81242-4
Subject(s) - embryo , embryonic stem cell , dna , embryogenesis , biology , binding protein , microbiology and biotechnology , chicken liver , dna binding protein , biochemistry , gene , transcription factor , enzyme
The relative amounts of a DNA‐binding protein of 34 kDa increased during the early stages of development of chick embryo liver. The content of this protein reached a maximum in 18‐19‐day‐old embryonic livers and decreased afterwards in older embryonic and post‐natal chick livers. The 34 kDa polypeptide is the major DNA‐binding protein (DBP) of embryonic liver and it preferentially binds to single‐stranded DNA. The quantity of the 34 kDa DBP was relatively very low in embryonic muscle, heart and brain.