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Tumour‐host metabolic interaction and cachexia
Author(s) -
Lazo Pedro A.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)81239-4
Subject(s) - cachexia , anorexia , biology , cancer research , amino acid , metabolic disorder , bioinformatics , endocrinology , computational biology , medicine , biochemistry , cancer , genetics
Cachexia is a terminal metabolic problem observed in a wide variety of tumours. In this article I propose that the syndrome is a direct consequence of the common feature to all malignant tumours: growth. I suggest that the requirement for essential amino acids can be used as the unifying principle that links the tumour to the two main components of cachexia: muscle wastage and anorexia. This underlying factor is usually clouded by the overlapping of individual tumour characteristics.