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A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle
Author(s) -
Muñoz Aira,
Lavandero Sergio,
Donoso Eduardo,
Puente Javier,
Sapag-Hagar Mario
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)81236-9
Subject(s) - forskolin , calmodulin , adenylate kinase , endocrinology , activator (genetics) , intracellular , medicine , cyclase , chemistry , receptor , biology , biochemistry , enzyme
The effect on lactose production of several external modulators of intracellular cyclic AMP was studied in rat mammary gland tissue slices and explants. Adrenaline, a β‐adrenergic receptor effector, forskolin, a direct adenylate cyclase activator and fluphenazine, a calmodulin inhibitor, all produced an increase in the intracellular level of cyclic AMP and a concomitant inhibition of lactose production. These results suggest a role for adrenaline and calmodulin in modulating cyclic AMP levels in mammary tissue during the lactogenic cycle.