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The amiloride sensitive Na + /H + antiport in guinea pig pancreatic acini
Author(s) -
Dufresne Marlène,
Bastie Marie-José,
Vaysse Nicole,
Creach Yves,
Hollande Etienne,
Ribet André
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)81227-8
Subject(s) - amiloride , antiporter , chemistry , guinea pig , ion transporter , cholecystokinin , medicine , endocrinology , biophysics , sodium , biochemistry , biology , receptor , membrane , organic chemistry
Amiloride and analogs decrease the initial rate of 22 Na + uptake by dispersed acini from guineapig pancreas in a dose‐dependent manner. The initial rate of amiloride‐sensitive 22 Na + uptake depends on external Na + and H + concentrations and on internal pH. These results provide evidence for the existence of a Na + H + antiport in pancreatic acinar cells. Caerulein, a cholecystokinin analog, stimulates the activity of the Na + /H + antiport.