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Thermodynamic limits to the stoichiometry of H + pumping by mitochondrial cytochrome oxidase
Author(s) -
Murphy M.P.,
Brown G.C.,
Brand M.D.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)81204-7
Subject(s) - cytochrome c oxidase , stoichiometry , oxidase test , cytochrome , chemistry , electron transport complex iv , mitochondrion , biochemistry , enzyme
H + /O stoichiometries of 0, 2 and 4 have been proposed for cytochrome oxidase. Here we show that a stoichiometry of 4 is thermodynamically impossible for rat liver cytochrome oxidase under normal conditions.