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Very low density lipoprotein triglyceride kinetics during hepatic lipase suppression by estrogen
Author(s) -
Tikkanen M.J.,
Kuusi T.,
Nikkilä E.A.,
Sane T.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)81134-0
Subject(s) - very low density lipoprotein , hepatic lipase , lipoprotein lipase , lipase , catabolism , triglyceride , medicine , endocrinology , chemistry , monoacylglycerol lipase , enzyme , lipoprotein , estrogen , biochemistry , cholesterol , biology , receptor , endocannabinoid system
The exact role of the heparin‐releasable hepatic endothelial lipase has remained controversial. It has been suggested that it acts in concert with lipoprotein lipase in the step‐wise delipidation of triglyceride‐rich lipoproteins. On the other hand, there is evidence indicating that high density Iipoprotein 2 is the preferred substrate for hepatic lipase. Here, it is shown that a moderate (27%) suppression of hepatic lipase activity by estrogen did not impair removal of 3 H‐labeled very low density lipoproteins (VLDL) triglycerides, suggesting that this enzyme is not a major regulator of VLDL catabolism under physiological circumstances.