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Cytoskeletal accumulation of a specific iso‐actin during chemotaxis of Dictyostelium
Author(s) -
McRobbie Stuart J.,
Newell Peter C.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)81121-2
Subject(s) - chemotaxis , cytoskeleton , dictyostelium , actin , microbiology and biotechnology , dictyostelium discoideum , biology , stimulation , chemistry , biochemistry , cell , neuroscience , receptor , gene
We have previously reported that stimulation of Dictyostelium amoebae with the chemoattractants folate or cAMP elicits a rapid (3–5 s) accumulation of actin in the Triton‐insoluble cytoskeleton, a response which may be involved in amoeboid movement (McRobbie and Newell, 1983, 1984). We have now measured the changes in the three major isoactin species A 1 A 2 , and A 3 present in the amoebal cytoskeletons and find that it is the most acidic isoactin A 1 that preferentially accumulates in the cytoskeleton in response to these chemotactic pulses. The differing roles of the isoactins are discussed