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The aerobic/anaerobic transition of glucose metabolism in Trypanosoma brucei
Author(s) -
Eisenthal Robert,
Panes Alison
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)81106-6
Subject(s) - trypanosoma brucei , anaerobic exercise , carbohydrate metabolism , metabolism , chemistry , biochemistry , anaerobic glycolysis , food science , biology , physiology , glycolysis , gene
The ratio of glycerol to pyruvate produced by T . brucei incubated with glucose at various oxygen tensions has been used as an index of the aerobic and anaerobic pathways of glucose metabolism. A minimal model is presented which fits the observed data. The value of the notional K of the aerobic/anaerobic transition from the model is close to that of the K m of trypanosomal glycerophosphate oxidase. The anaerobic pathway appears to be almost completely inoperative at oxygen tensions in the range of those found in venous and arterial blood.