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Antiviral activity of phorbol myristate acetate and possible relationships with interferon action
Author(s) -
Premecz György,
Markovits Andrea,
Földes István
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)81090-5
Subject(s) - diacylglycerol kinase , protein kinase c , phorbol , arachidonic acid , prkcq , diglyceride , mechanism of action , inositol , signal transduction , second messenger system , chemistry , phospholipid , biochemistry , interferon , protein kinase a , stimulation , microbiology and biotechnology , phorbol ester , biology , kinase , enzyme , membrane , receptor , endocrinology , in vitro , immunology
Signal‐induced turnover of membrane phospholipids represents a fundamental transducing mechanism that induces a signal cascade resulting in mobilization of calcium, activation of protein kinase C by diacylglycerol, release of arachidonic acid and stimulation of cyclic GMP production. In this pathway tumor‐promoting phorbol esters such as phorbol myristate acetate (PMA) may substitute for diacylglycerol. The interferonlike antiviral effect of PMA described here suggests that the inositol phospholipid‐diacylglycerol‐protein kinase C signal‐transducing mechanism may be involved in interferon action.