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Transient transcriptional inhibition of the transferrin gene by cyclic AMP
Author(s) -
Tuil David,
Vaulont Sophie,
Levin Mariano J.,
Munnich Arnold,
Moguilewsky Martine,
Bouton Marie M.,
Brissot Pierre,
Dreyfus Jean-Claude,
Kahn Axel
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)81046-2
Subject(s) - transferrin , medicine , endocrinology , hormone , glucagon , gene expression , transcription (linguistics) , transferrin receptor , biology , gene , messenger rna , chemistry , biochemistry , linguistics , philosophy
Transferrin mRNA content and gene transcription rate were measured in the liver of rats submitted to iron overload or depletion, castration, treatment with sexual steroid hormones, glucagon and cyclic AMP. The influence of puberty in males and females and of pregnancy was also analysed. Glucagon and cyclic AMP reduced mRNA level by about 50% at the 12th hour of treatment and transferrin gene transcription by as muchas 95% at the 30th minute of drug infusion, with a secondary increase of the transcription rate for a protracted treatment. None of the other hormones tested had any detectable effect on transferrin gene expression, the same being true for iron overload or depletion.