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On the physico‐chemical rationale of the genetic code
Author(s) -
Rèmme Jaanus,
Villems Richard
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)81015-2
Subject(s) - genetic code , proofreading , transfer rna , reactivity (psychology) , codon usage bias , chemistry , genetics , computational biology , biochemistry , biology , amino acid , genome , rna , gene , medicine , alternative medicine , pathology , polymerase
We analysed two different and seemingly independent aspects of protein biosynthesis: the primary structure of codons and the reactivity of aminoacyl groups. This analysis revealed that more reactive aminoacyl groups correspond to less stable codon‐anticodon complexes. The possible meaning of such a correlation is discussed in terms of the kinetic proofreading theory.