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Na + ‐channel antagonists act as electron donors while agonists act as electron acceptors in reactions with dye free radicals
Author(s) -
Marinov Beniamin S.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)81014-0
Subject(s) - radical , chemistry , tetrodotoxin , photochemistry , electron transfer , biophysics , organic chemistry , biology
The reactions of Na + ‐channel antagonists and agonists with dye free radicals were studied by the methods of pulse and continuous absorption spectroscopy. All Na + antagonists tested except tetrodotoxin act as electron donors while agonists act as electron acceptors in the reactions with photogenerated dye free radicals. Qualitative correlation between electron donor activity of the Na + ‐channel blockers and their electrophysiological potency was observed. The relation of discovered regularity to the Na + channel operating was discussed.