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Birhythmicity in a model for the cyclic AMP signalling system of the slime mold Dictyostelium discoideum
Author(s) -
Goldbeter Albert,
Martiel Jean-Louis
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)81012-7
Subject(s) - dictyostelium discoideum , slime mold , signalling , desensitization (medicine) , positive feedback , biological system , reset (finance) , mycetozoa , dictyostelium , biology , biophysics , chemistry , microbiology and biotechnology , receptor , biochemistry , economics , engineering , financial economics , electrical engineering , gene
We demonstrate the coexistence of two simultaneously stable periodic regimes in a model based on receptor desensitization for the cyclic AMP signalling system of the slime mold Dictyostelium discoideum . These results provide the first example of autonomous birhythmicity in a biochemical model closely related to experimental observations. Whereas the transition from one stable mode of oscillations to the other can be elicited by suprathreshold stimuli, the two periodic regimes differ in their sensitivity to perturbations. That multiple oscillations occur in a model based on a single feedback loop suggests that the conditions for birhythmicity are widely satisfied in biological systems.