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Increased β‐aminoisobutyric acid in rat liver with 6‐azauracil and its enantiomer
Author(s) -
Tamaki Nanaya,
Fujimoto Shigeko,
Mizutani Naomi,
Mizota Chizuru
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)81004-8
Subject(s) - aminoisobutyric acid , alanine , enantiomer , chemistry , thymine , beta (programming language) , amino acid , stereochemistry , biochemistry , dna , computer science , programming language
When 6‐azauracil was subcutaneously injected, β‐aminoisobutyric acid and β‐alanine contents were increased 22 and 61‐fold, respectively, in rat liver. Incorporation of [methyl‐ 14 Cithymine into β‐aminoisobutyric acid was increased to 42‐fold by 6‐azauracil treatment. The absolute configuration of this amino acid was proved to be the ( R )‐form by means of a gas‐chromatographic technique. 6‐Azauracil inhibited β‐alanine‐pyruvate aminotransferase activity with an I 50 of approx. 2.5 mM.