Premium
Oxyntomodulin (glucagon‐37) and its C‐terminal octapeptide inhibit gastric acid secretion
Author(s) -
Jarrousse Claire,
Audousset-Puech Marie-Pascale,
Dubrasquet Marcelle,
Niel Huguette,
Martinez Jean,
Bataille Dominique
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80879-6
Subject(s) - pentagastrin , glucagon , secretion , endocrinology , gastric acid , medicine , chemistry , gastrointestinal hormone , peptide hormone , biology , hormone
Oxyntomodulin (OXM) is a peptide isolated from porcine intestine which consists of the whole glucagon sequence with a basic octapeptide (KA 8 ) at its C‐terminal end. In this study, the effect of OXM and KA 8 on pentagastrin‐stimulated gastric acid secretion has been studied in conscious rats and cats. In rats, OXM (25–450 pmol·kg −1 ) as well as KA 8 (7.5–60 nmol·kg −1 ) inhibited pentagastrin‐stimulated gastric acid output in a dose‐dependent manner; KA 8 was about 100‐times less potent than OXM. In cats, KA 8 (90 nmol·kg −1 ) was also an inhibitor of acid secretion. We conclude that OXM, or a closely related peptide, could be a physiological modulator of gastric acid secretion, and that the C‐terminal octapeptide of OXM is implicated in this effect.