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Chemiosmotic coupling in cytochrome oxidase
Author(s) -
Mitchell Peter,
Mitchell Roy,
John Moody A.,
West Ian C.,
Baum Harold,
Wrigglesworth John M.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80863-2
Subject(s) - cytochrome c oxidase , chemistry , electron transport chain , coupling (piping) , cytochrome , oxidase test , cytochrome c1 , chemiosmosis , biochemistry , biophysics , cytochrome c , enzyme , coenzyme q – cytochrome c reductase , biology , atp synthase , mitochondrion , materials science , metallurgy
Using the principle of specific vectorial ligand conduction, we outline directly coupled protonmotive O loop and O cycle mechanisms of cytochrome oxidase action that are analogous to protonmotive Q loop and Q cycle mechanisms of QH 2 dehydrogenase action. We discuss these directly coupled mechanisms in the light of available experimental knowledge, and suggest that they may stimulate useful new research initiatives designed to elucidate the osmochemistry of protonmotive oxygen reduction in cytochrome oxidase.