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A second human calcitonin/CGRP gene
Author(s) -
Steenbergh P.H.,
Höppener J.W.M.,
Zandberg J.,
Lips C.J.M.,
Jansz H.S.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80820-6
Subject(s) - calcitonin gene related peptide , calcitonin , gene , thyroid carcinoma , thyroid , endocrinology , neuropeptide , medicine , medullary carcinoma , biology , receptor , genetics
The calcitonin (CT) gene is alternatively expressed in a tissue‐specific fashion producing either the calcium regulatory hormone CT in the thyroid or the neuropeptide calcitonin gene related peptide (CGRP) in the brain. In medullary carcinoma of the thyroid both peptides are produced. We present here evidence for the existence in the human genome of a second CT gene, which is also expressed in human medullary thyroid carcinoma. This gene encodes a second human CGRP, differing from the known human CGRP in 3 of the 37 amino acids.