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Synthesis of a nonacosapeptide (β‐fragment) corresponding to the N‐terminal sequence 1–29 of human liver metallothionein II and its heavy metal‐binding properties
Author(s) -
Okada Yoshio,
Ohta Noriya,
Yagyu Masami,
Min Kyong-Son,
Onosaka Satomi,
Tanaka Keiichi
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80813-9
Subject(s) - metallothionein , chemistry , sequence (biology) , cysteine , human liver , fragment (logic) , peptide sequence , metal , metal ions in aqueous solution , stereochemistry , metalloprotein , biochemistry , microbiology and biotechnology , biology , enzyme , gene , organic chemistry , computer science , programming language
A nonacosapeptide (β‐fragment) corresponding to the N‐terminal sequence 1–29 of human liver metallothionein II was synthesized by the fragment condensation method. The Cd‐binding ability of the β‐fragment was much stronger than that of cysteine as thionein and synthetic α‐fragment corresponding to the C‐terminal sequence 30–61 of human liver metallothionein II. Both the α‐ and β‐fragments bound preferentially to Cu ions rather than Cd ions.