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Pertussis toxin inhibits chemotactic factor‐induced phospholipase C stimulation and lysosomal enzyme secretion in rabbit neutrophils
Author(s) -
Bradford Peter G.,
Rubin Ronald P.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80801-2
Subject(s) - secretion , chemotaxis , pertussis toxin , stimulation , phospholipase c , phospholipase , toxin , enzyme , chemistry , phospholipase d , endocrinology , biology , medicine , biochemistry , g protein , signal transduction , receptor
Pertussis toxin suppressed [ 32 P]polyphosphoinositide breakdown and lysosomal enzyme secretion induced by fMet‐Leu‐Phe in rabbit neutrophils. Likewise, fMet‐Leu‐Phe‐ or leukotriene B4‐evoked ( 3 H]inositol trisphosphate accumulation was inhibited by the toxin. These findings, taken together with evidence that pertussis toxin specifically causes inactivation of the guanine nucleotide binding protein (N i ), suggests that guanine nucleotide binding proteins may mediate coupling between calcium‐mobilising receptors and phospholipase C‐mediated reactions in rabbit neutrophils.