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Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions
Author(s) -
Favaron Marco,
Bernardi Paolo
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80789-4
Subject(s) - uniporter , mitochondrion , calcium , magnesium , intracellular , chemistry , kidney , biophysics , biochemistry , biology , microbiology and biotechnology , endocrinology , cytosol , enzyme , organic chemistry
This paper analyzes the kinetics of the Ca 2+ uniporter of mitochondria from rat heart, kidney and liver operating in a range of Ca 2+ concentrations near the steady‐state value (1–4μM). Heart mitochondria exhibit the lowest activity, and physiological Mg 2+ concentrations inhibit the mitochondrial Ca 2+ uniporter by approx. 50% in heart and kidney, and by 20% in liver. At physiological Ca 2+ and Mg 2+ concentrations the external free Ca 2+ maintained by respiring mitochondria in vitro is higher in heart and kidney with respect to liver mitochondria. This behaviour could represent an adaptation of different mitochondria to their specific intracellular environment.