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Study of hepatic binding protein activity in jejuno‐ileal by‐passed rat hepatocytes
Author(s) -
Serbource-Goguel Nathalie,
Dodeur Michèle,
Borel Béatrice,
Feger Jeanne,
Agneray Jean,
Durand Geneviève
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80783-3
Subject(s) - internalization , receptor , endocrinology , medicine , chemistry , endogeny , biology , biochemistry
The kinetic constants of internalization of asialoorosomucoid were determined for normal and jejuno‐ileal by‐passed rat hepatocytes. In by‐passed rats the maximum velocity of asialoorosomucoid internalization is decreased 3‐fold, without any modification of apparant constant of internalization. Moreover, the rate constant of internalization was the same in the two groups of rats. These data suggest that the process of asialoorosomucoid internalization is not altered in by‐passed hepatocytes and that the decrease of maximal velocity is only due to a decrease of total uptake receptor number.