Premium
GTP enhances inositol trisphosphate‐stimulated Ca 2+ release from rat liver microsomes
Author(s) -
Dawson A.P.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80759-6
Subject(s) - gtp' , inositol , inositol trisphosphate , chemistry , incubation , microsome , polyethylene glycol , inositol phosphate , biochemistry , vesicle , biophysics , in vitro , membrane , biology , receptor , enzyme
Low concentrations of GTP (10–50 μM) greatly enhance the inositol 1,4,5‐trisphosphate stimulated Ca 2+ release from rat liver microsomal vesicles. The effect of GTP depends on the presence of low concentrations of polyethylene glycol in the incubation medium. Guanylyl imidodiphosphate is ineffective at mimicking the GTP effect and inhibits the action of GTP added subsequently.