Premium
Amino acid sequence of an amyloidogenic Bence Jones protein in myeloma‐associated systemic amyloidosis
Author(s) -
Tonoike Hiroshi,
Kametani Fuyuki,
Hoshi Akihiko,
Shinoda Tomotaka,
Isobe Takashi
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80757-2
Subject(s) - bence jones protein , amyloidosis , peptide sequence , sequence (biology) , immunoglobulin light chain , al amyloidosis , multiple myeloma , amino acid , alanine , chemistry , myeloma protein , protein primary structure , residue (chemistry) , lambda , biochemistry , microbiology and biotechnology , medicine , antibody , biology , immunology , pathology , gene , physics , optics
The complete amino acid sequence of an amyloidogenic Bence Jones protein(NIG‐84) from an individual with myeloma‐associated systemic amyloidosis has been determined. The protein, with a blocked N‐terminus, represents a complete light chain consisting of 217 residues and it has a structural feature characteristic of the Vλ II subgroup. In addition to a two‐residue insertion at positions 28 and 29, it has an additional rare insertion of alanine at position 100. NIG‐84 is an example of the first complete sequence presented for the amyloidogenic Bence Jones protein of the Vλ II subgroup.