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Degradation mediated OH radical generation from synthetic cyclic peroxides: ESR studies
Author(s) -
Matsugo Seiichi,
Kayamori Nobuko,
Hatano Yoshihiko,
Ohta Tatsuo,
Konishi Tetsuya
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80645-1
Subject(s) - chemistry , scavenger , reagent , alkoxy group , degradation (telecommunications) , decomposition , spin trapping , thermal decomposition , radical , medicinal chemistry , hydroxyl radical , photochemistry , organic chemistry , telecommunications , alkyl , computer science
Hydroxy radical generation on thermal decomposition of synthetic cyclic peroxides was determined by ESR using DMPO as a spin‐trapping reagent. Both the 6‐ and 7‐membered cyclic peroxides, 4‐alkoxy‐2,3‐benzodioxan‐1‐ols and 4‐alkoxy‐2,3‐benzodioxepin‐1‐ols, respectively, which were synthesized according to our idea of a radical‐releasing drug, gave rise to DMPO‐OH signals on heat treatment, i.e. under their degradation conditions. The signals were completely abolished with higher concentrations of OH scavenger.